葡萄球菌中對mupirocin、有抗藥性的有多少? (這是美國Houston數據)

Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children.

Antimicrob Agents Chemother.  2011; 55(5):2431-3 (ISSN: 1098-6596)

McNeil JC ; Hulten KG ; Kaplan SL ; Mason EO
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Feigin Center, Suite 1150, 1102 Bates St., Houston, TX 77030, USA.

Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P=0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.

PreMedline Identifier:21282426

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.