Posted: 12/06/2010; American Journal of Health-System Pharmacy. 2010;67(23):2015-2024. © 2010 American Society of Health-System Pharmacists, Inc.
Abstract and Introduction
Abstract
Purpose. The chemistry, pharmacology, antimicrobial activity, pharmacokinetics, pharmacodynamics, efficacy and safety in humans, and formulary considerations of doripenem are reviewed.
Summary. Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive bacteria; enteric and nonenteric gram-negative bacteria, including extended-spectrum β-lactamase-producing strains; and anaerobic pathogens. Doripenem was found to be noninferior to meropenem in the treatment of complicated intraabdominal infections and noninferior to levofloxacin in the treatment of complicated urinary tract infections including pyelonephritis and was granted marketing approval by the Food and Drug Administration for these two indications. Doripenem was also found to be noninferior to imipenem in the treatment of ventilator-associated pneumonia and noninferior to piperacillin–tazobactam in the treatment of hospital-acquired pneumonia. It has a favorable safety profile, with gastrointestinal complaints and headache being the most common adverse effects and allergic reactions the most serious adverse effects. Doripenem has a relatively low potential to induce seizures. The only known clinically relevant drug interaction is that coadministration with valproic acid may result in reductions of valproic acid serum concentrations. As with most renally eliminated antibiotics, the dose of doripenem should be adjusted according to kidney function.
Conclusion. Doripenem is an injectable carbapenem antibiotic with a spectrum of activity comparable to that of imipenem and meropenem. Its safety is similar to that of other carbapenems.
[和 imipenem or meropenem 差不多就是了！]
許醫師:您還在讀這些雜誌嗎?真佩服!
回覆刪除從FAPA回來了!心情好一點嗎?
有進(從事自己專長)有出(出席同好團體)、人生最快樂!
我訂閱 Medscape Best Evidence, Medscape Infectious Disease, Medscape Daily News等，幾乎每天會寄來好論文或新聞。以前我是儲存在 My Documents內，可是不會再翻開來，全忘光了。現在想到登在BLOG上，還會複習一下，比較好。
回覆刪除FAPA 理事會中遇到很多相同理念的台美人（Taiwanese-American），談得非常暢快。回家後忙著寄像片，計畫登相片在BLOG上、也考慮寄一篇有關同學(陳傳峰)的美談給景福醫訊。
發現有些人已經從太平洋時報或景福讀過我的文章，對我有鼓勵的作用。不過我還沒開始動工，要再兩、三天才開始衝。
看了你寫的文章，吐吐氣也是很好。很多台灣人不知道民主、法治。被「高級外省人」、台奸騙了，還洋洋得意，以為是「中間選民」。
許醫師:我想您一定是走在「醫學(感染症)」最前端、我雖也找(醫學)書看、但都是雜書、論文都不敢碰。難怪、經常有許多人都向您「挖寶」!
回覆刪除依許醫師的update、2012年奪回政權後、再回台灣當顧問1~2年如何!我還有點期待呢!